Applications:
Electron Microscopy -
Immunogold labelling is the most widely used methodology in electron
microscope Immunocytochemistry. Gold labels are very electron-dense
and can be readily distinguished from cellular components.
Light Microscopy - Immunogold staining
in combination with silver enhancement is a rapid, sensitive
technique which permits very precise localization of antigen
compared to enzymatic detection methods.
Blotting -
Immunogold conjugates may be used with silver enhancement to
visualize DNA, RNA or proteins on nitrocellulose, PVDF or nylon
membranes
“In Situ” Hybridization -
Specific DNA and RNA sequences can be readily be identified using
gold labelling after in situ” Hybridization with biotinylated or
digoxigenin labelled DNA probes.
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